Fareston is a non-steroidal anti-tumor drug with anti-estrogenic effect. It is produced in the form of flat tablets (20 or 60 mg). One tablet contains 20 (60) mg of Toremifene Citrate. The active ingredient belongs to triphenylethylene derivatives. Fareston is used in medical practice for the treatment of breast cancer caused by excessive estrogen activity.
Fareston effectively inhibits the growth of breast tumors. Toremifene inhibits cell replication and blocks DNA synthesis caused by estrogens. When used in high dosages, it has anti-tumor effect (not associated with estrogen-dependent effects). The main active ingredient of the drug helps fight tumor cells and cause their death. The drug helps minimize painful breast engorgement and significantly reduce fibrosis or cystic formation. Besides, it helps prevent the formation of new pathologies. The drug increases progesterone levels and gradually decreases prolactin level, which has a beneficial effect in the therapy.
According to instructions, Fareston is used in the treatment of the following diseases: hormone-dependent metastatic breast cancer (in postmenopausal women); dyshormonal hyperplasia of the breast.
Fareston (Toremifene Citrate) contraindications
According to instructions, Fareston has the following contraindications: endometrial hyperplasia, thromboembolism, pregnancy and lactation, hypersensitivity to the drug, severe hepatic impairment. Fareston is used with caution in patients with metastatic bone disease, thrombocytopenia, leukopenia and hypercalcemia.
The drug is contraindicated during pregnancy and breastfeeding.
Dosage indications for Fareston (Toremifene Citrate)
Fareston tablets can be taken without regard to meals. Patients are advised to take 60 mg daily as the standard dose for first-line hormonal treatment. As for the second-line therapy, the daily dose may be increased to 240 mg.
Women with dyshormonal hyperplasia of the breast usually take 20 mg per day.
Women with estrogen-dependent breast cancer usually take 60 mg per day (once daily).
The recommended dose should not be reduced in renal insufficiency.
Possible side effects from taking Fareston (Toremifene Citrate)
According to the reviews, the drug is well tolerated in most patients. But in some cases Fareston may cause the following side effects: vaginal discharge or bleeding, dizziness, itching in the genital area, fatigue, depression, hot flashes, increased sweating, nausea, insomnia. Less commonly observed adverse reactions include: shortness of breath, headache, blurred vision (cataract, corneal clouding), hearing loss, venous thrombosis, abnormal liver function tests, pulmonary embolism, jaundice (in very rare cases). In case of overdose (more than 680 mg per day), Fareston may cause vomiting, fainting, headache, nausea.
Digestive tract: loss of appetite, vomiting, nausea, high AST and ALT levels, jaundice.
CNS: depression symptoms, sleep disturbances, dizziness, vertigo, headache.
Cardiovascular system: thromboembolism (deep venous thrombosis, thrombophlebitis and pulmonary embolism).
Other reactions: dyspnea, alopecia, endometrial polyps, endometrial hyperplasia, edema, weight gain, cataract, corneal opacity.
Toremifene has no mutagenic and teratogenic properties and does not lead to the development of hepatocellular carcinoma and endometrial cancer.
Special instructions when taking Fareston (Toremifene Citrate)
All patients must undergo a vaginal examination to start Fareston therapy. The first stage is mucosal examination of the endometrium, as the risk of hyperplasia, polyposis and endometrial cancer increases due to the effects of estrogen stimulation. Patients with cardiovascular disease (as well as with bone metastases) require more careful observation.
Do not mix Fareston with the following medicines: neuroleptics (phenothiazines, pimozide, sertindole, haloperidol, sulpiride), some antibacterial agents (moxifloxacin, erythromycin, pentamidine, certain antimalarial medications), some antihistamines (terfenadine, astemizole, mizolastine), some anti-arrhythmic drugs (amiodarone, sotalol, dofetilide, ibutilide, disopyramide), some other drugs (bepridil, diphemanil, cisapride, vincamine). Concomitant use of thiazide diuretics may lead to the development of hypercalcemia. Some anticoagulants may increase the length of bleeding time.
The drug should be stored at a temperature between 15 and 25° C.
Fareston (Toremifene Citrate) for athletes in endurance sports
Fareston is one of the new drugs in bodybuilding (approved by the FDA in 1997). Drugs like Fareston are popular with bodybuilders as they help avoid water retention, weight gain and gynecomastia. It is used in order to reduce complications and side effects after the course of anabolic steroids and androgens. Also, Fareston is popular among athletes during the post cycle therapy (to restore production of natural testosterone).
Fareston is the closest relative of Tamoxifen and Clomid. This is a selective estrogen receptor modulator (SERM) from the new generation of anti-estrogen drugs to combat estrogen-dependent breast cancer in women. It is often used if Tamoxifen is not effective. According to general research, Toremifene is more active than Tamoxifen.
Toremifene appeared in Finland in order to replace Tamoxifen, which had many side effects. In general, it has the same effect as Tamoxifen and Clomiphene. The essential difference from the above-mentioned drugs is significantly lower severity of side effects. Here is the list of side effects that may occur in patients using Toremifene Citrate:
- Hot flashes (20%);
- Sweating (14%);
- Nausea (8%);
- Dizziness (4%);
- Peripheral edema (3%).
In addition, Toremifene is less toxic to the liver. One can say that Toremifene is a modified version of Tamoxifen. It helps restore endogenous testosterone levels after the course of steroids with minimal side effects.
What is the practical value of Fareston in power sports? In principle, it can serve as a complete substitute for Tamoxifen and Clomid during PCT (post cycle therapy). However, it is a little bit unreasonable because of the high price of the drug.
As for Clomid, it makes sense to use this drug only after the steroid cycle. However, it is too weak to avoid the phenomena of feminization (especially taking into account the common doses of steroids). So, let’s leave this issue alone.
As for Tamoxifen, this drug has a very unpleasant feature. In some cases, when used in parallel with progestins (Deca, Trenbolone, Oxymetholone), it is able to significantly increase side effects associated with progestogenic activity: excessive fluid retention, gynecomastia, weight gain, inhibition of the reproductive system. Tamoxifen affects the growth of progestagenic receptors. That is, this drug is undesirable during and immediately after the cycle with progestins.
As for Fareston, this drug helps avoid the estrogenic side effects of Nandrolone and Oxymetholone. Toremifene dose ranges from 20 to 60 mg per day. Athletes who took Toremifene during PCT leave positive feedbacks for this drug.
It is worth noting that it is possible to start using Fareston only under the supervision of a physician. Of course, this drug is not a panacea. Nevertheless, Fareston is certainly more effective in comparison with its main analogue – Tamoxifen.