HCG or Human Chorionic Gonadotropin is a hormone released by the placenta during pregnancy. This hormone has the same properties as gonadotropin produced by the pituitary gland.

According to the biochemical composition, HCG belongs to the group of glycoprotein hormones – complex proteins connecting polypeptide and carbohydrate components.

Normally, HCG is not present in men and non-pregnant women. The concentrations of Human Chorionic Gonadotropin would rise from the first days of pregnancy. HCG is first produced in fetal membranes, and then – in placental cells. Once in the blood, this hormone is excreted unchanged in the urine. Pharmaceutical preparations of Human Chorionic Gonadotropin obtained from the urine of pregnant women are available under various trade names.

HCG (Human Chorionic Gonadotropin) effects:

  • Stimulation of sex hormone synthesis (mainly testosterone);
  • Activation of spermatogenesis;
  • Development of male secondary sexual characteristics.

HCG can improve sperm quality. That’s why gonadotropin preparations are used for the stimulation of testosterone production in the following diseases: secondary hypogonadism, disorders of spermatogenesis in the form of oligospermia, azoospermia, asthenospermia, cryptorchidism, testicular hypoplasia, idiopathic male infertility.

HCG (Human Chorionic Gonadotropin) recommendations
Human Chorionic Gonadotropin is an agent that helps athletes avoid temporary testicular atrophy and also restore the normal testicular function (in those who already have atrophy). This rule applies mainly to professional athletes who take steroids on a regular basis and in very large doses.

HCG (Human Chorionic Gonadotropin) absolute contraindications:

  • Prostate cancer;
  • Mammary tumors.

General contraindications:

  • Hypersensitivity to the drug;
  • Pituitary tumors;
  • Severe heart failure;
  • Renal failure;
  • Bronchial asthma;
  • Epilepsy.

HCG (Human Chorionic Gonadotropin) in bodybuilding

Human Chorionic Gonadotropin is widely used by athletes for stimulation of production of sex hormones and prevention of testicular atrophy. For this reason it is included in the list of recommended drugs to recover from steroid cycles. HCG is mainly used during long-term courses of anabolic steroids. Human Chorionic Gonadotropin is not used for women.

Gonadotropin should not be used as a muscle-building agent, because it may be dangerous to health. This hormone is less efficient in comparison with anabolic steroids. Moreover, it is possible to have some noticeable gains only when using high doses of HCG (more than 4000 IU per week), which can have a negative effect on the HPG axis.

Meanwhile, gonadotropin has no serious harmful effects in post cycle therapy, as in this case you will be using a much smaller daily dose.

HCG (Human Chorionic Gonadotropin) dosage
After the injection, the hormone is completely removed within several hours. Meanwhile, the effect will last about 5-6 days.

The dosage of the drug in post cycle therapy is highly dependent on the steroid course. If you take a short course of steroids (4 weeks) and use only one product in small doses, it means you can go without HCG. If you are taking long courses (more than 4 weeks) and use 2 or more steroids, the gonadotropin dosing will be 2 injections per week (500-1000 IU each). Professional athletes who use anabolic steroids almost all the time should use this on a regular basis (with a break for 1-2 weeks after 5 weeks of therapy).

When using gonadotropin for weight loss, the optimal dosage is the following: 1 injection per day (500 IU each).

It is important to use the drug properly, since it may cause unwanted side effects. The following are the most common reactions: acne, hair loss, decrease in gonadotropin-releasing hormone, hair growth on the face and body, gynecomastia, enlarged prostate, masculinization, abnormalities of the hypothalamic–pituitary–gonadal axis.

HCG (Human Chorionic Gonadotropin) Side effects

When used in large doses over long periods of time, HCG may lead to gonadotropin-releasing hormone (GnRH) deficiency and disorders of the hypothalamic-pituitary-gonadal axis (HPG axis).

Athletes should use HCG very carefully, as it may cause a number of side effects. The most common side effect in bodybuilders is considered to be potency disorder. In addition, Human Chorionic Gonadotropin may cause gynecomastia (inflammation of the mammary glands in men). Uncontrolled use may result in acne and fluid retention. HCG can also lead to the development of androgen-dependent tumors, ovarian tumors, and worsen conditions for people with hypertension and renal insufficiency. Prolonged administration of HCG can lead to allergic reactions. Young athletes should use other drugs instead of HCG, because it can affect normal bone development. Few people believe that athletes using HCG may suffer from symptoms similar to the signs of pregnancy, that is, morning sickness, weight gain, breast growth, etc. There are other unpredictable side effects that can be linked with HCG.

When used in women for whatever reason, Human Chorionic Gonadotropin can induce the development of ovarian hyperstimulation syndrome. This may lead to the development of tumors and cysts, especially in the presence of genetic predisposition. In this case, surgical intervention may be needed to remove the ovaries. HCG may also lead to a variety of menstrual disorders. There is an increased risk of miscarriage, multiple pregnancy, and lactation problems. The risk of complications in women is much higher than that of men.


Gonadotropin is a hormone, which is widely used to treat certain problems of the reproductive system. The injections are used to treat disorders of spermatogenesis, male infertility, etc. Moreover, this drug is used for the prevention of testicular atrophy in bodybuilders. HCG is widely used in strength sports during post cycle therapy. Nevertheless, uncontrolled use of HCG can lead to gynecomastia and other disorders.

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